产品货号：
Z17325
中文名称：
GIT1抗体
英文名称：
Anti-GIT1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-GIT1 Antibody |
| 指标别名 | ARF GAP GIT1;CAT 1;CAT1;GIT1;GRK interacting protein 1 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,ICC/IF,FCM,ELISA |
| 基因名称 | GIT1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human GIT1 recombinant protein (Position:D415-Q736). |
| 实际分子量 | 84KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | ARF GTPase-activating protein GIT1 is an enzyme that in humans is encoded by the GIT1 gene.G-protein coupled receptor (GPCR) kinase interacting proteins 1 and 2 (GIT-1 and GIT-2) are highly conserved,ubiquitous scaffold proteins involved in localized signaling to help regulate focal contact assembly and cytoskeletal dynamics.GIT proteins contain multiple interaction domains that allow interaction with small GTPases (including ARF,Rac and cdc42),kinases (such as PAK and MEK),the Rho family GEF PIX,and the focal adhesion protein paxillin.GIT-1 is localized to focal adhesions,cytoplasmic complexes and membrane protrusions,and regulates cell protrusion formation and cell migration.GIT-1 has also been implicated in neuronal functions including synapse formation and the pathology of Huntington disease.Huntington disease is a genetic neurodegenerative condition involving a mutation in the huntington gene.The huntington gene product (htt) is ubiquitinated and degraded in human Huntington disease brains.Htt interacts directly with GIT-1 causing enhanced htt proteolysis,indicating that GIT-1 distribution and function may contribute to Huntington disease pathology. |
| Uniprot ID | Q9Y2X7 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot. |
| 基因名全称 | GIT ArfGAP 1 |
| 蛋白名全称 | ARF GTPase-activating protein GIT1 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry (IHC) 1:50～400 Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells Enzyme linked immunosorbent assay (ELISA) 1:100～1000 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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